Cannabis may affect platelet aggregation. THC and CBD may also inhibit the enzyme that clopidogrel needs to use to be metabolized which can lead to an increase of clopidogrel in your body. Using cannabis and clopidogrel together may increase your risk of bleed. Tell you healthcare prescriber if you use cannabis and take clopidogrel. Monitor for signs and symptoms of bleeding (increased bruising, gums bleed when brushing teeth, easily bruising, cuts that won't stop bleeding or take a long time to stop bleeding even with added pressure). Do not change or alter your medications before talking with your health care prescriber.